Toxic shock syndrome and sepsis-induced cholestasis are the foremost common causes of jaundice in the intensive care unit. A rare cause of jaundice is autoimmune haemolytic anaemia (AIHA). We present a case in which recurrent Escherichia coli sepsis induced a Coombs-positive AIHA leading to jaundice. Although AIHA induced by Gram-negative shock is rare, it needs to be considered in the absence of alternative causes to prevent delay of treatment.
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