N-methyl-D-aspartate (NMDA) receptor antibody encephalitis is an immunotherapy-responsive panencephalitis. Patients usually present with characteristic clinical features in a specific order. We describe a patient who developed anti NMDA receptor encephalitis with a positive liquor EBV titer, suggesting formation of antibodies including anti NMDA. After a prolonged ICU stay the patient had a slow but full recovery. Despite severe neurological symptoms, in general, the prognosis of anti NMDA receptor encephalitis is good and warrants prolonged intensive care treatment when indicated.
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